IVF Outcomes After PPOS Versus Flexible GnRH-Antagonist Protocol in Advanced-Age Women With Diminished Ovarian Reserve: A Retrospective Study.
Zhang J, Bai L, Wang S, Yu C, Wang X, Zhou J, Hu L, Chen L, Hu H
Abstract
Background Infertility affects 8%-12% of couples worldwide; advanced maternal age combined with diminished ovarian reserve (DOR) significantly lowers IVF success. The flexible GnRH-antagonist and progestin-primed ovarian stimulation (PPOS), are increasingly adopted for freeze-all strategies in this poor-prognosis population; however, their relative effectiveness remains inconclusive. Methods This retrospective study (January 2017-April 2022) enrolled only women ≥ 35 years with diminished ovarian reserve (AMH Results This study included 141 patients with DOR who underwent the flexible GnRH-ant protocol ( n = 58) or PPOS protocol ( n = 83). In oocyte retrieval cycles, the flexible GnRH-ant group had higher numbers of retrieved oocytes, MII mature oocytes, normally fertilized oocytes, cleaved embryos, available embryos, and good-quality embryos than the PPOS group (all p p Conclusion Although the quality and quantity of the embryos was different, the good-quality embryo rate and pregnancy outcomes were similar in FET cycles between the flexible GnRH-ant protocol and PPOS protocol in advanced maternal age with DOR.